Respiratory |
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· | Incidence
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· | More than 5 million children under the age of 6 experience lower respiratory tract infections (LRTI) each year in the U.S.
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· | Between 50-90% of LRTIs in children are caused by viruses
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· | Viruses are the fourth leading cause of hospital-treated pneumonia in otherwise healthy adults
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· | Age bimodal peaks
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· | Children <10 years
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· | Adults >55 years
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· | Although a wide variety of viral agents are capable of causing LRTI in adults and children, respiratory syncytial virus (RSV), adenovirus, influenza A and B, and parainfluenza 1, 2, and 3 cause 80-90% of LRTIs
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· | RSV and influenza are viruses associated with significant annual morbidity and mortality, and which have available therapies
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· | RSV causes 50-90% of bronchiolitis infections and 5-40% of pneumonitis infections in children
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· | Influenza can cause significant disorder in adults and children
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· | Age <2 years or >55 years
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· | Compromised immune system
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· | Preexisting chronic medical condition (cardiac, pulmonary, hepatic)
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· | Clinical presentation often does not distinguish viruses
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· | Nonspecific symptoms of cough, fever, sore throat, rhinorrhea, hoarseness, bronchitis, croup and bronchiolitis
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· | Complications
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· | Infants, the elderly, and individuals with compromised cardiac, pulmonary or immune systems are at greatest risk for serious complications from LRTI
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· | Severe viral pneumonia
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· | Acute respiratory failure
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· | Secondary bacterial pneumonia
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