RBC Morphology
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RBC Morphology |
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Would you like to know what lab results mean? Medical Tests Analyzer Software will explain and clarify your lab test report. |
| · | RBC with a diameter >8µm
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| · | RBC thinner than normal (e.g. target cells) with normal MCV may appear as 'macrocytes'
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| · | Found in megaloblastic anemia (oval acrocytes); liver disorder, alcoholism, neonates, reticulocytosis
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| · | RBC diameter < 6.4µm
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| · | Found in iron deficiency anemia, thalassemia, hyperthyroidism
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| · | RBC of unequal size
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| · | Found in almost all red-cell diseases; non-specific; arked anisocytosis may be said to be normocytic
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| · | Oval and elliptical cells
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| · | Found in hereditary elliptocytosis, iron deficiency anemia, myelofibrosis
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| · | Tear-drop appearance
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| · | Found in myelofibrosis, when bone marrow is replaced by non-haemopeitic tissue, and with extramedullary erythropoiesis
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| · | Intermmediate sickling : rod-shaped, boat shaped and oat shaped
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| · | Found in sickle cell anemia
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| · | The fragment are small and often appear spherical, triangular or irregular, deeply stained with irregular outline
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| · | Found in haemolytic anemia, burns, thalassemias, megaloblastic anemia, iron deficiency anaemia, elliptocytosis, DIC, thrombotic thrombocytopenic purpura, drug and toxins
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| · | Multiple short symmetric projection (10-30 spicules of equal length) due to disc-sphere transformation
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| · | Found as artifact (in stored blood, alkaline pH), in gross electrolyte imbalance
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| · | Irregular, unequal spicules (8-12 pointed projections) with a-beta-lipoproteinemia with markedly reduced lecithin content in cell membrane
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| · | Found in splenectomy, McLeod phenotype of Kell blood group
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| · | Irregular asymmetric projections, small cells or fragments
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| · | Found in uremia
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| · | RBC with long irregularly spaced projections
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| · | Found in liver disorder, normal infants, uremia, DIC, thrombotic thrombocytopenic purpura
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| · | Loss of bi-concavity (loss of surface membrane lipid, excessive sodium influx), smaller diameter, dense-staining
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| · | Found in hereditary spherocytosis or induced by chemicals or bacterial toxins or antibodies
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| · | Increased surface area (due to increased cholesterol and lecithin) with same volume
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| · | Found in obstructive liver disorder, Hb C, D and E disorders; iron deficiency anemia
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| · | RBC with narrow slit-like area of central pallor
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| · | Found in hereditary stomatocytosis, liver disorder with alcohol abuse; in Rh-null genotype
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| · | Erythrocytes with nuclei
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| · | Found in severe anemia(except aplastic), myelofibrosis, severe heart failure, hemolytic anemia.
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| · | Pale staining of RBC due to thin cell and low Hb conc
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| · | Found in iron deficiency, thalassemia, sideroblastic anemia
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| · | Reticulocytes with residual RNA have affinity for basic components of stain (blue)
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| · | Found in response to blood loss, haemolysis or haematinic therapy
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| · | Presence of two populations of RBC : hypochromic with normochromic, macrocytic/microcytic with normocytic
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| · | Found in sideroblastic anemia,megaloblasltic anaemia/iron deficiency anemia after treatment and after transfusion, Cooley's aneamia after transfusion
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| · | Reticulocytes
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| · | Aggregate ribosomes RNA.
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| · | Howell-Jolly bodies:
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| · | DNA nuclear remnants, single deep purple of varying size; found in post-splenectomy, hyposplenism, megalobalstic anaemia, haemolytic anaemia.
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| · | Pappenheimer bodies:
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| · | Ferric compound complexed with protein; small dark blue bodies of uniform size, usually occur singly with absent splenic function.
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| · | Basophilic stippling = punctate basophilia
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| · | Aggregates of Ribrosomes, Multiple blue black inclusions evenly distributed; found in lead poisoning, thalassemias.
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| · | Heinz bodies
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| · | (by supravital staining, better with methyl violet, brilliant green is specific to Heinz bodies) Single round cell structure of denatured Hb at cell margin, as white unstained areas in MGG stain if haem is lost); found in post-splenectomy, due to oxidant stress of drugs and chemicals on unstable Hb (G6PD deficiency).
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| · | Hb H inclusion bodies
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| · | (supravital stain with new methylene blue, brilliant cresyl blue)
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| · | Precipitate tetramers of beta-globin chains;
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| · | Golf-ball appearance.
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| · | Siderocytes
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| · | RBC with aggregates of ferritin or hemosiderin , demonstrated by Prussian blue.
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| · | Sideroblast
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| · | Nucleated red cell containing ferritin molecules (up to 5 or more); found in iron deficiency and infection, "ringed" sideroblast is a characteristic feature of sideroblastic anaemia.
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| · | Cabot ring and chromatin dust
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| · | Remnants of mitotic spindle of nuclear membrane, altered microtubules;
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| · | Found in failure of erythropoiesis or in extramedullary blood formation.
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| · | Microorganism (Bartonella bacilliformis) and protozoa (Malaria parasite)
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