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Hypersegmented neutrophils have classically been thought to be pathognomonic of the class of anemias called megaloblastic anemias (anemias caused by failure of bone marrow blood-forming cells to make DNA, often caused by vitamin B12 or folate deficiencies, or DNA-replication poisons). A neutrophil is considered as hypersegmented when the number of segments exceeds five. The hypersegmentation is an indicator of senescence. The corticosteroids, whether of endogenous or exogenous origin could contribute to this phenomenon. It have strongly associated neutrophil hypersegmentation with iron deficiency anemia. Also associated with vitamin B12 deficiency, folate deficiency, anti-metabolite therapy or alcoholism.
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