Thrombophilia (Hypercoagulable state) (Coagulopathy)

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Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occurs in the deep veins of the legs. Affected people also have an increased risk of developing a pulmonary embolism, which is a clot that travels through the bloodstream and lodges in the lungs. Most people with prothrombin thrombophilia never develop abnormal blood clots. The disorder is the propensity to venous thrombosis due to an abnormality in the coagulation system. It may be inherited or acquired, although in some cases the underlying cause has not been identified. Many factors contribute to the hypercoagulable state. Inherited thrombophilia affects up to 10% of the population; acquired risk factors, such as obesity and hormonal therapy, are frequent in the community. Most patients with heritable thrombophilia remain asymptomatic. Venous thromboembolism is the most common manifestation of the hypercoagulable state. It can be prevented in some patients with identification of those at risk and appropriate thromboprophylaxis during periods of high risk, such as admission to the hospital and following major surgery.

Symptoms:

Laboratory Test Procedures:

feet swelling
pain, numbness, weakness or coldness in legs or arms
ongoing irritation, swelling, and painful rashes on the legs
legs often ache and feel heavy and itchy
redness
skin swelling
discoloration
distention of surface veins
skin that feels warm to the touch
shortness of breath
chest pain
coughing up blood
coughing
coughing at night
pale gray or blue skin color
sweating
fast heartbeat
irregular heartbeat
decreased pulses in the feet
fainting
lightheadedness

Protime/INR
PTT
D-dimer (fibrin degradation products)
Platelet Count
Fibrinogen
Schistocytes/OPF
Sickle
Homocysteine
Hematocrit
RBC
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